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EMESSA Labs for Pharmaceutical Industries was established in 1958
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IMILIN

Product Name:
IMILIN
Composition:

Each tube contains :
Lidocaine 2.5 %
Prilocaine 2.5 %

Pharmaceutical Form:

Cream & Ointment

Packing:

Cream 7.5 gr

Public Price:

 75 sp

Pharmacist Price:

 63 sp

Pharmacologic Category:

Dermal and Genital

Properties:

IMILIN Cream is a mixture of two local anaesthetics, Lidocaine and Prilocaine,
combined with special agents which allow the products to pass through the skin.
When applied to intact skin under occlusive dressing , it provides dermal analgesia by accumulation of Lidocaine and Prilocaine in the vicinity of dermal pain receptors and nerve endings.

Indications:

1- IMILIN Cream (a eutectic mixture) is indicated as a topical anesthetic for use on normal intact skin for local analgesia .
2- Premature Ejaculation: IMILIN Cream has been applied topically to the penis for a desensitising effect in the management of premature ejaculation. The cream is usually applied to the penis, then washed off before sexual intercourse. A study of different application times found 20 minutes to be the optimum.

Contraindications:

IMILIN is contraindicated in patients with a known history
of sensitivity to local anesthetics of the amide type or to any other component of the product.

Side Effects:

Localized Reactions: During or immediately after treatment with IMILIN, the skin at the site of treatment may develop erythema or edema or may be the locus of abnormal sensation. Rare cases of discrete purpuric or petechial reactions at the application site have been reported.
These reactions are generally mild and transient , resolving spontaneously within 1 or 2 hours .
Allergic Reactions: Allergic and anaphylactoid reactions associated with lidocaine or prilocaine can occur. If they occur they should be managed by conventional means.
Systemic (Dose Related) Reactions: Systemic adverse reactions following appropriate use of IMILIN are unlikely due to the small dose absorbed and
are similar in nature to those observed with other amide local anesthetic agents including CNS excitation and/or depression (like light-headedness, nervousness,dizziness,tinnitus,vomiting,sensations of heat, twitching,convulsions).
Cardiovascular manifestations may include bradycardia, hypotension and cardiovascular collapse leading to arrest.

Precautions:

1-Allergies you have to any:
• Ingredients in the cream.
• Any local anaesthetic, for example those used at the dentist
2-Any of these medical conditions:
• dermatitis
• methemoglobinemia or patients taking drugs associated with drug-induced methemoglobinemia .
• Severe hepatic disease.

Dosage:

1-Surface/ Age: Skin
Application: A thick layer of the cream to the skin , under an occlusive dressing.

2- Surface/ Age: Adults.
-Procedures: Minor procedures ,e.g. needle insertion and surgical treatment of localized lesions Application: 1 g/10 cm².
-Procedures: Dermal procedures on larger areas, e.g. split – skin grafting.
Application: Approx. 1.5-2 g/10 cm²for a minimum of 2 hours , maximum 5 hours.

3- Surface/ Age: Children.
Procedures: Minor procedures ,e.g. needle insertion and surgical treatment of localised lesions.
Application:
- Neonates 0-2 months: Up to 1 g and 10 cm².
- Infants 3-11 months: Up to 2 g and 20 cm².
- Children 1-5 years: Up to 10 g and 100 cm².
- Children 6-11 years: Up to 20 g and 200 cm².

4 -Surface/ Age: Genital mucosa/ Adults.
Procedures: Surgical treatment of localised lesions, e.g. removal of genital warts (condylomata acuminata) and prior to injection of injection of local anesthetic.
Application: Approx.5 – 10 g IMILIN for 5-10 minutes. No occlusive dressing is required.

5 -Surface/ Age: Leg ulcer /Adults.
Procedures: Mechanical cleaning / debridement of leg ulcers(s).
Application: Apply a thick layer of the cream, approx.1-2 g/ 10 cm² up to a total of 10 g to the leg ulcer(s).
Cover with a occlusive dressing.
Application time: at least 30 minutes.
Up to 60 minutes may improve the anesthesia further.Cleansing should start without delay after removal of the cream.