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EMESSA Labs for Pharmaceutical Industries was established in 1958
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Product Name:

Spironolactone 25 mg

Pharmaceutical Form:



20 F.C.Tabs.

Public Price:

 115 sp

Pharmacist Price:

 95 sp

Pharmacologic Category:



Spironolactone is a specific pharmacologic antagonist of aldosterone , acting primarily through competitive binding of receptors at the aldosterone – dependent sodium – potassium exchange site in the distal convoluted renal tubule . Spironolactone causes increased amounts of Sodium and water to be excreted, while Potassium is retained, Spironolactone acts both as a diuretic and as an antihypertensive drug by this mechanism.


Spiractone is used in the treatment of :
- Refractory edema in patients with congestive heart failure, nephrotic syndrome cirrhosis of liver and malignant ascites .
- Diagnosis and treatment of primary hyperaldosteronism .
- Essential hypertension .


Actue renal insufficiency, significant impairment of renal excretory function, anuria, and hyperkalemia, sensitivity to Spironolactone, pregnancy and lactation .

Side Effects:

Drowsiness , headache , slight and transient disorientation symptoms, digestive disturbances,dermic allergic reactions, gynecomastia, libido disturbance and mild androgenic reactions, hyponatremia and hyperkalemia.
These effects usually disappear after discontinuation from therapy.

Drug Interactions:

-Spiractone should not be given with other Potassium sparing diuretics or Potassium supplements.
-Spiractone enhances the effects of other antihypertensive drugs.
-Salicylates reduce the action of Spiractone .
-Spiractone may diminish vascular response to noradrenaline and the activity of warfarin.


-Treatment of primary hyperaldosteronism : 400 mg daily of Spironolactone in divided doses, then the dose reduces and changes as the response of the patient.
-Essential hypertension : the initial dosage 100 –200 mg daily in divided doses, treatment should be continued for at least tow weeks since an adequate response may not occur before this time, dosage should subsequently be adjusted according to the response of the patient .
-Congestive heart failure : usual dose 100 mg per day. In difficult or severe cases the dosage may be gradually increased up to 200 mg daily .
-Cirrhosis of liver : If the Sodium / Potassium ratio in the urine is smaller than
1 : 100 mg daily, if the ratio is bigger than 1 : 200 – 400 mg daily .
Maintenance dosage should be individually determined .
-Nephrotic syndrome : usually 100 – 200 mg daily .
-Oedema in children : 1.5 – 3mg / kg. of body weight in divided doses .